Prevalence of preclinical and clinical heart failure in the elderly. A population-based study in Central Italy

Gian Francesco Mureddu1*, Nera Agabiti2, Vittoria Rizzello1, Francesco Forastiere2, Roberto Latini3, Giulia Cesaroni2, Serge Masson3, Giuseppe Cacciatore1,
Furio Colivicchi4, Massimo Uguccioni5, Carlo Alberto Perucci1, and
Alessandro Boccanelli1, on behalf of the PREDICTOR Study Group†

 

Heart failure (HF) is an important public health problem in the Western world, as it is associated with high morbidity, high mortal- ity, and considerable healthcare costs.1 In Italy, 􏰀 200 000 hospita- lizations per year (88% among people aged .65 years) are registered with the main diagnosis of HF, and the trend is increas- ing.2 In the general population, HF prevalence increases with age and is high in the elderly.3 – 6 A preclinical phase of HF (stage B

of HF), characterized by changes in cardiac geometry or asymp- tomatic left ventricular dysfunction (ALVD), has been identified as associated with a poor prognosis.5,7,8 The available evidence indicates that early pharmacological strategies may prevent HF in the preclinical stage of HF,9 and guidelines suggest a preventive ap- proach.7,8 The prevalence of ALVD varies widely in the general population, ranging from 1% to 34%,4,5,10 – 13 depending on the characteristics of the study population, the definition of LVD and symptoms, and the method used to detect LVD.13 In general,

the elderly tend to show the highest prevalence of ALVD.3,12,14 However, since there are scant data on the prevalence of ALVD and HF in elderly people, particularly in Southern Europe and in the Mediterranean area, there is a specific need for investigation of this issue.

We report the results of a large-scale epidemiological study (PREDICTOR; Valutazione della PREvalenza di DIsfunzione Cardi- aca asinTOmatica e di scompenso caRdiaco) aimed at estimating the prevalence of HF and asymptomatic LVD in men and women aged 65–84 years randomly selected in the Lazio region in Central Italy.